Risks of sedating infants
Methotrexate: Caution should be exercised if NSAIDs and Methotrexate are administered within 24 hours of each other, since NSAIDs may increase Methotrexate plasma levels, resulting in increased toxicity.
PREGNANCY & LACTATION There is no information on the use of Aceclofenac during pregnancy.
Anticoagulants: Like other NSAIDs, Aceclofenac may enhance the activity of anticoagulant.
It should not be administered to patients with active or suspected peptic ulcer or gastrointestinal bleeding and moderate to severe renal impairment.DRUG INTERACTIONS Lithium and Digoxin: Aceclofenac, like many NSAIDs may increase plasma concentrations of lithium and Digoxin.Diuretics: Aceclofenac, like other NSAIDs, may interact the activity of diuretics.The mean plasma elimination half-life is around 4 hours. Aceclofenac circulates mainly as unchanged drug, 4-Hydroxy Aceclofenac is the main metabolite detected in plasma.
Approximately two-thirds of the administered dose is excreted via the urine, mainly as hydroxymetabolites.Aceclofenac PRESENTATION Aclonac Tablet: Each film-coated tablet contains Aceclofenac BP 100 mg.PHARMACOLOGY Aceclofenac is a non-steroidal agent with marked anti-inflammatory and analgesic properties.Adult: For sexually transmitted disease caused by Chlamydia trachomatis the dose is 1 g as a single dose.